The information below is provided for educational purposes only and is not medical advice. Medication decisions should always be made in consultation with a licensed healthcare provider.
Semaglutide and Tirzepatide are once-weekly injectable medications that may be prescribed for chronic weight management in eligible adults, alongside lifestyle changes such as nutrition and physical activity.
Both medications act on hormones involved in appetite regulation and blood sugar control. Semaglutide works on GLP-1 receptors, while Tirzepatide works on both GLP-1 and GIP receptors. Many people experience reduced appetite and increased feelings of fullness.
In clinical studies, Tirzepatide has shown greater average weight loss compared to Semaglutide. However, individual results vary, and effectiveness depends on factors such as medical history, tolerance, and adherence to treatment.
The most common side effects for both medications are gastrointestinal and may include nausea, vomiting, diarrhea, constipation, or abdominal discomfort. These effects are most common during dose increases and often improve over time.
These medications have been studied extensively and are FDA-approved for specific uses. They are not appropriate for everyone. A provider will review your medical history to determine whether treatment is safe and appropriate for you.
In some cases, switching may be considered, but this should only be done under medical supervision. A provider will determine whether a switch is appropriate and how it should be managed safely.
Choosing a medication depends on multiple factors, including your health history, prior experience with similar treatments, side effect tolerance, availability, and cost. These considerations are best discussed directly with a licensed provider.
| Feature | Semaglutide | Tirzepatide |
|---|---|---|
| Medication class | GLP-1 receptor agonist | GLP-1 + GIP receptor agonist |
| Injection frequency | Once weekly | Once weekly |
| Average weight loss in studies | Significant | Greater on average |
| Appetite suppression | Yes | Yes (often stronger) |
| Common side effects | Nausea, GI discomfort | Nausea, GI discomfort |
| Dose adjustments | Gradual increase over time | Gradual increase over time |
| Who may prefer it | Those seeking a well-established option with extensive clinical data | Those seeking potentially greater average weight loss, depending on tolerance |
Individual results vary. A licensed provider will help determine whether medication is appropriate and which option may be best.